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KMID : 0882420100780050564
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Korean Journal of Medicine
2010 Volume.78 No. 5 p.564 ~ p.574
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The mechanism and treatment of anti-viral resistant hepatitis B virus
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Song Byung-Cheol
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Abstract
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Even though substantial advances have been made in the treatment of chronic hepatitis B in the past decade with the use of oral nucleos(t)ide analogues (NAs), emergence of anti-viral resistance is the most important factor in treatment failure for chronic hepatitis B. Therefore, prevention and management of antiviral resistant HBV is major challenge in the era of oral NAs therapy. Recently, several guidelines for the management of antiviral resistant HBV have been published. Herein, I will discuss how to prevent and manage antiviral resistance. (Korean J Med 78:564-574, 2010)
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KEYWORD
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Chronic hepatitis B, Antiviral resistance, Nucleos(t)ide analogues, Combination therapy
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